(54) Three-dimensional Molecular Imaging by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry Dreidimensionale Molekulare Bildgebung Mittels Infrarot-laserablation- Elektrospray-ionisation-massenspektrometri E Imagerie Moleculaire Tridimensionnelle Par Spectrometrie De Masse

نویسنده

  • PETER NEMES
چکیده

(72) Inventors: • VERTES, Akos Reston VA 20190 (US) • NEMES, Peter Silver Spring MD 20906 (US) • PETER NEMES ET AL: "Ambient Molecular Imaging and Depth Profiling of Live Tissue by Infrared Laser Ablation Electrospray Ionization Mass Spectrometry",ANALYTICAL CHEMISTRY, vol. 80, no. 12, 1 June 2008 (2008.06-01), pages 4575-4582, XP55024857, ISSN: 0003-2700, 001: 10.1021/ac8004082 • "Generation of three-dimensional images in mass spectrometry", , 16 May 2003 (2003-05-16), XP55024986, Retrieved from the Internet: URL: http://www.hipo-online.de/files/Exp_Hi po_3D_ MS_EN_160503.pdf [retrieved on 2012-04-19] • PETER NEMES ET AL: "Three-Dimensional Imaging of Metabolites in Tissues underAmbient Conditions by Laser Ablation Electrospray Ionization Mass Spectrometry", ANALYTICAL CHEMISTRY, vol. 81, no. 16,15 August 2009 (2009-08-15), pages 6668-6675', XP55024885, ISSN: 0003-2700, 001: 10.1021/ac900745e

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ambient molecular imaging and depth profiling of live tissue by infrared laser ablation electrospray ionization mass spectrometry.

Mass spectrometry in conjunction with atmospheric pressure ionization methods enables the in vivo investigation of biochemical changes with high specificity and sensitivity. Laser ablation electrospray ionization (LAESI) is a recently introduced ambient ionization method suited for the analysis of biological samples with sufficient water content. With LAESI mass spectrometric analysis of chimer...

متن کامل

Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Ambient ionization methods in mass spectrometry allow analytical investigations to be performed directly on a tissue or biofilm under native-like experimental conditions. Laser ablation electrospray ionization (LAESI) is one such development and is particularly well-suited for the investigation of water-containing specimens. LAESI utilizes a mid-infrared laser beam (2.94 μm wavelength) to excit...

متن کامل

Spatially resolved in vivo plant metabolomics by laser ablation-based mass spectrometry imaging (MSI) techniques: LDI-MSI and LAESI

This short review aims to summarize the current developments and applications of mass spectrometry-based methods for in situ profiling and imaging of plants with minimal or no sample pre-treatment or manipulation. Infrared-laser ablation electrospray ionization and UV-laser desorption/ionization methods are reviewed. The underlying mechanisms of the ionization techniques-namely, laser ablation ...

متن کامل

Three-dimensional imaging of metabolites in tissues under ambient conditions by laser ablation electrospray ionization mass spectrometry.

Three-dimensional (3D) imaging of molecular distributions offers insight into the correlation between biochemical processes and the spatial organization of a biological tissue. Simultaneous identification of diverse molecules is a virtue of mass spectrometry (MS) that in combination with ambient ion sources enables the atmospheric pressure investigation of biomolecular distributions and process...

متن کامل

Three-dimensional Molecular Imaging by Infrared Laser Ablation Electrospray Ionization Mass Spec Trome Try

U.S. PATENT DOCUMENTS 5,012,052 A 4/1991 Hayes 5,338,930 A 8/1994 Chu et al. 5,965,884 A 10/1999 Laiko et al. 6,495,824 B1 12/2002 Atkinson 6,531,318 B1 3/2003 Palmer-Toy et al. 6,548,263 B1 4/2003 Kapur et a1. 6,558,946 B1 5/2003 Krishnamurthy 6,656,690 B2 12/2003 Crooke et al. 6,744,046 B2 6/2004 Valaskovic et a1. 6,941,033 B2 9/2005 Taylor et a1. 6,949,741 B2 9/2005 Cody et a1. 6,989,528 B2 ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013